Accomodation and CVS

05/09/2019 by Bynocs0
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Digital eye strain: prevalence, measurement and amelioration

Abstract:

Digital device usage has increased substantially in recent years across all age groups, so that extensive daily use for both social and professional purposes is now normal. Digital eye strain (DES), also known as computer vision syndrome, encompasses a range of ocular and visual symptoms, and estimates suggest its prevalence may be 50% or more among computer users. Symptoms fall into two main categories: those linked to accommodative or binocular vision stress, and external symptoms linked to dry eye. Although symptoms are typically transient, they may be frequent and persistent, and have an economic impact when vocational computer users are affected.

DES may be identified and measured using one of several available questionnaires, or objective evaluations of parameters such as critical flicker–fusion frequency, blink rate and completeness, accommodative function and pupil characteristics may be used to provide indices of visual fatigue. Correlations between objective and subjective measures are not always apparent. A range of

management approaches exist for DES including correction of refractive error and/or presbyopia, management of dry eye, incorporating regular screen breaks and consideration of vergence and accommodative problems. Recently, several authors have explored the putative role of blue light-filtering spectacle lenses on treating DES, with

mixed results. Given the high prevalence of DES and near- universal use of digital devices, it is essential that eye care practitioners are able to provide advice and management options based on quality research evidence.

Introduction:

Computer vision syndrome (CVS) is characterised by a range of eye and vision-related symptoms and has been a recognised health problem for over 20 years.1 2 The terms visual fatigue (VF) and digital eye strain (DES) are also used for the condition, reflecting the variety of digital devices linked to potential problems. These expressions may be more appropriate for communication with patients and the public, who may not consider devices such as tablets and smartphones to be computers.3 Given the massive growth in digital device usage in recent years, many millions of individuals of all ages are at risk of DES. While symptoms are usually transient, the condition can cause significant, frequent, discomfort for sufferers and may have substantial economic consequences when vocational computer users are affected through increased errors and more frequent breaks.4

The following review considers new findings in this active field. Recent data and informa- tion on usage of digital devices, assessment techniques and management of the condi- tion are presented. Furthermore, in addition to the more commonly described subjective techniques (ie, questionnaires) that are used in this area of research, objectively deter- mined indicators of DES are considered

Use of digital devices:

Across all age groups in developed nations, engagement with digital devices has increased substantially in recent years, particularly in the field of mobile media.5 A multination Euro- pean study including England, reported that by 3 years of age, 68% of children regularly use a computer and 54% undertake online activities.6 In 2016, it was estimated that UK adults typically spend 4 hours 45 min per day using digital media,7 with a similar pattern in the USA, where approximately two-thirds of adults aged 30–49 years spend five or more hours on digital devices.8

In older  age  groups,  use  of  technology  is growing rapidly (figure 1) between 2011 and 2017, the proportion of the population classed as ‘recent internet users’ (within the last 3 months) more than doubled in the 75 years and over age group, and increased from 52.0% to 77.5% in those aged 65–74 years.9 Recent US data indicate that 37% of adults aged 60 years and over spend five or more hours per day using digital devices, and this age group prefers using laptops and desktops for browsing the internet, whereas younger adults are more likely to use smartphones for this purpose.8 Use of social media and multitasking is particularly prominent among younger adults with 87% of individuals aged 20–29 years reporting use of two or more digital devices simultaneously.

Symptoms and Prevaience:

According to the American Optometric Association,10 the most common symptoms

associated with DES are eyestrain, headaches, blurred vision, dry eyes and pain in the neck and shoulders. Asthenopia is the formal term for eye strain, for which two distinct mechanisms and sets of symptoms were described by Sheedy et al.11 External symptoms of burning, irritation and tearing and dryness were noted to be closely related to dry eye, while internal symptoms of strain, ache and headache behind the eyes were linked to accommodative and/or binocular vision stress. Similarly, Portello et al12 also identified a clear split of computer-related symptoms into two categories: those associated with accommoda- tion (namely, blurred vision at near, blurred distance vision after computer use and difficulty refocusing from one distance to another) and those that seemed linked to dry eye (irritated/burning eyes, dry eyes, eyestrain, headache, tired eyes, sensitivity to bright lights and eye discomfort).

The prevalence of DES has received attention in the scientific literature for over 20 years. Gauging prevalence is challenging due to the wide variety of usage conditions (both vocationally and socially) and substantial changes in these over time, along with the range of methodolo- gies that have been applied to identify sufferers. Recent data, representative of contemporary devices and usage patterns, indicate that DES is a very common problem affecting many millions of individuals. The 2016 Digital Eye Strain report,8 which included survey responses from over 10 000 US adults, identified an overall self-re- ported symptom prevalence of 65%, with females more commonly affected than males (69% vs 60% prevalence). DES was reported more frequently by individuals who used two or more devices simultaneously, compared with those using just one device at a time, with prevalences of 75% and 53%, respectively. The finding of greater computer-related symptoms in females was in agreement with 2012 findings among a cohort of 520 office workers

in New York City12 and may be linked to gender differ- ences in dry eye prevalence.13 14 For 10 defined symptoms, Portello et al12 documented that each symptom had been experienced by over 50% of respondents at least ‘some of the time’ during computer use within the last week. As shown in table 1, each symptom was reported half of the time or more during computer use over the last week in 17.3%–39.8% of respondents, highlighting the poten- tially persistent and frequent nature of DES complaints was 53%.15 With six or more hours of computer use, contact lens wearers were more likely to be affected than non-wearers, with prevalences of 65% and 50%, respec- tively. The finding was attributed to possible incomplete removal of superficial deposits with multipurpose lens care solutions and/or the mechanical interaction of sili- cone hydrogel lenses with the ocular surface.15

Considering dry eye disease (DED) specifically in computer users, a recent meta-analysis including data from 11 365 individuals estimated an overall prevalence of 49.5%, ranging from 9.5% to 87. 5%.14 While these values appear higher than the 5%–33% DED prevalence observed in the general population,16 the heterogeneity of diagnostic criteria for DED used in studies to date mean that the overall figure has limited value. Standardised criteria for DED diagnosis and universal implementation would enable more robust estimates of the prevalence of the condition among computer users. The recent  Tear Film and Ocular Surface Society Dry Eye Work- shop II report included detailed recommendations for diagnostic methodology.17 Key proposals were symptom screening with either the Ocular Surface Disease Index (OSDI) or Dry Eye Questionnaire (DEQ-5) instruments, followed by objective clinical tests in DED suspects, including breakup time (preferably non-invasive), osmo- larity and ocular surface staining with fluorescein and lissamine green.17

The problem of dry eye linked to digital device usage

is not limited to adults. Recent studies based in South Korea have indicated that longer daily durations of both visual display terminal (VDT)18 and smartphone18 19 use are risk factors for DED in children. Cessation of smart- phone use for a 4-week period in children with DED aged 7–12 years resulted in significant improvements in non-invasive tear breakup time, punctate epithelial erosion and OSDI scores, with all affected children no longer being classified as DED sufferers at the end of the abstinence period.19 The prevalence of DES in paediatric populations has received little attention in the literature to date, although a recent meta-analysis of available data linked to asthenopia in children20 reported a pooled prevalence of 19.7%. A scarcity of data in this field was highlighted, along with difficulties comparing studies due to the variation in methods. Given that asthenopia may impact on learning and school performance, and children are increasingly heavy users of digital devices, further research is needed to gauge the prevalence and consequences of the condition in children.

Among 426 civil servants in Spain, the overall preva- lence of DES (detected using a validated questionnaire)

Figure 1 Recent internet use (within the last 3 months) among UK adults in 2011 and 2017. Data obtained from the Office for National Statistics.9

Table 1 Percentage of respondents (n=520 New York City office workers) reporting symptoms during computer use at least half of the time over the last week. Data extracted from Portello et al12

SymptomPercentage of respondents reporting symptom at least half of the time.
Blurred vision while viewing the computer17.3
Blurred vision when looking in to the distance23.4
Difficulty or slowness in refocusing my eyes from one distance to another21.6
Irritated or burning eyes27.5
Dry eyes31.5
Eye strain30.6
Headache22.3
Tired eyes39.8
Sensitivity to bright lights26.3
Eye discomfort30.8

MeasurIng DES subjective methods:

A variety of instruments have been used to identify DES sufferers and grade the severity of complaints. A 10-item questionnaire created by Hayes et al21 has been deployed in several subsequent studies12 22 and relates to the level of ocular discomfort experienced from the symptoms listed in table 1, enabling calculation of a total symptom score. The six-item Visual Fatigue Scale requires users to respond using a Likert scale to difficulties in seeing, strange feeling around the eyes, eyes feeling tired, feeling numb, having a headache and feeling dizzy looking at the screen. It has been applied to study symptoms following the use of e-readers, indicating that reading from liquid crystal display (LCD) screens (eg, tablet devices) triggers more subjectively reported VF than reading from paper copies or e-ink displays.23

The Rasch-based Computer-Vision Symptom Scale (CVSS17)24 was developed in Spanish to measure visual and ocular symptoms in computer users. An English version of the questionnaire may be obtained, although currently, normal CVSS values dependent on race and other factors are unknown. Seguí and colleagues25 developed the first validated questionnaire in English  to evaluate DES in the workplace. The self-administered Computer Vision Syndrome Questionnaire (CVS-Q) requires users to indicate the frequency and intensity  of 16 symptoms experienced during computer use, allowing a single symptom severity score (CVS score) to be deduced, where six points or more is considered diag- nostic of the condition. The CVS-Q was used to analyse CVS in contact lens wearers.15 Questionnaires with veri- fied validity and reliability are useful tools to incorporate into regular patient care and clinical trials linked to ocular and visual health of workers engaged in computer use. Subjective questionnaires have also been used to provide additional validation for objective measures of VF,26 which are considered in the following section.

OIbjective evaluation:

Although DES affects a huge number of individuals, its precise physiological basis remains unclear. An array of measures of visual function have been used to provide indices of VF: accommodation parameters have received a significant amount of research attention given the accommodative nature of several DES symptoms, while critical flicker–fusion frequency (CFF) and blinking characteristics have been used regularly in recent DES research

 

Critical flicker–fusion frequency:

CFF is a recognised metric indicative of fatigue and mental workload27 and is the frequency at which a flickering light is indistinguishable from a steady, non-flickering light. A decline in this parameter has been attributed to reduced activity of the retina and/or optic nerve.28 Nega- tive changes in CFF following a prolonged computer task were observed to correspond with certain subjective ocular complaints (pain in/around the eyes, eyes feeling heavy and itchy eyes) in a recent study on the effects of short wavelength-blocking spectacles,29 although not all studies using the measure have established a correlation between worsening of CFF and increased symptoms.30 31 CFF may be influenced by task time, with Chi and Lin26 reporting a significant increase in the sensitivity of this parameter to load differences when task duration was extended. For a 0.4 Hz tracking task, mean post-task CFF reductions were 1.2±1.5 Hz and 2.2±0.7 Hz for 20 min and 60 min durations, respectively.26

Blinking and squinting:

Blinking aids maintenance of a normal ocular surface, with most blinks instigating a cycle of secretion, dispersal, evaporation and drainage of tears.32 Reduced blink rate with computer use has been observed in numerous studies33–35 and may be relevant to dry eye symptoms that frequently occur with DES. Reductions in blink rate may be substantial, for example, Patel et al33 reported a mean rate of 18.4 blinks/min before computer use, decreasing to 3.6 blinks/min during operation, while Tsubota and Nakamori35 observed a mean rate of 22 blinks/min among office workers under relaxed conditions, reducing to seven blinks/min when viewing an electronic display.

Sheedy et al36 hypothesised that reduced blink rate may be a consequence of involuntary squinting under symp- tom-producing conditions, with squinting contributing to asthenopia. Two potential benefits arise from squinting: improvement in visual acuity with refractive error and decreasing retinal illumination in the presence of a glare source in the superior visual field.37 The voluntary squint response, measured using electromyography (EMG) of the orbicularis oculi, influences blink rate significantly, with greater squint levels causing more substantial reduc- tion of blink rate.36 A later study,38 exposing participants to various asthenopic conditions during computer use including small font size, low contrast, induced refrac- tive error and glare revealed that conditions that may  be improved by squinting (refractive error and glare) showed an increased EMG response from the orbicularis oculi along with an increase in blink rate, while those that would not benefit from squinting (small font size and low contrast) showed no significant EMG response but a reduction in blink rate. Blink inhibition may arise from high cognitive demand or low-legibility conditions neces- sitating a lengthening of fixation duration and allowing increased time to acquire visual information.

Increased cognitive demand (eg, reading more chal- lenging material) exacerbates the effect of visual stressors such as low contrast or refractive error.39 Rosenfield et al40 exposed 16 teenage subjects to texts of two distinct levels of cognitive demand, both on a modern tablet computer and hard copy printed versions. Changing the cognitive demand had a greater impact on blink rate than presen- tation format. Mean blink rates for the low demand task were 8.34 and 9.06 blinks/min for the tablet and paper presentations, respectively, reducing significantly to 7.43 and 6.67 blinks/min, respectively, for the high demand task. It is possible that technological improvements in digital displays mean that they are more similar to printed materials, so the substantial reductions in blink rate with computer use reported in older studies may not be indic- ative of modern effects.

Although reduced blink rate may be a less pertinent issue now, many individuals continue to experience signs and symptoms of dry eye associated with digital device usage. Incomplete blinking, where the upper eyelid does not cover the entire corneal surface, may be more rele- vant to dry eye than blink rate as tear film stability can be maintained with a reduced blink rate, providing that most blinks are complete.41 Incomplete blinking can result in increased evaporation and tear film break up due to reduced tear film thickness in the inferior corneal region.42 Argilés et al43 observed a reduction in blink rate during reading tasks on tablet and computer displays (table 2), as well as hard copy text. However, reading from a hard copy was associated with a significantly lower proportion of incomplete blinks (0%–5%) compared with reading from a tablet (14.5%), expanded computer display (13.5%) or electronic reading (9%; see table 2). The specific influence of digital devices on incomplete blinks is unclear, and further research is needed to address this issue, along with the possible benefits of blink training.

Experimental conditionSpontaneous blink rate, blinks/ min Median (IQR) Median (IQR)% Incomplete blinks Experimental condition
Baseline: viewing picture at 2 m 15.5 (16)14.5 (29.5)
Tablet: reading at 45° angle at 40 cm 6 (11)14.5 (28.5)
PC: reading at 100% magnification at 60 cm 6.5 (11)9 (20)
PC: reading at 300% magnification at 60 cm11.5 (11)13.5 (25.8)
Text: pasted on switched off display at 60 cm7 (12)0 (16.3)
Text: on book rest at 45° angle at 40 cm5 (10)5 (22.8)
Text: read aloud at 45° angle at 40 cm4 (9)0 (14.5)

Table 2 Blink rate and proportion of incomplete blinks for various hard copy text and electronic reading conditions, as reported by Argilés et al43

Accommodative effects:

To perform near tasks comfortably, pre-presbyopes must be able to accommodate rapidly and smoothly and main- tain an accurate response.44 The lag of accommodation when viewing computer displays has been studied by several authors. Wick and Morse45 reported from a small sample of young adults that lag (measured with an open- view autorefractor) was approximately 0.33 D higher in 4 of 5 participants when reading from a VDT compared with printed material, although Penisten et al46 found similar lags (by dynamic retinoscopy) in printed and VDT condi- tions. More recently, Collier and Rosenfield47 reported a stable mean lag of approximately 0.93 D among 20 adults during a 30 min laptop-based task. Notably, no differ- ences in static accommodation responses were identified between the most symptomatic and least symptomatic groups, although the task duration may not characterise heavy usage patterns of digital devices.

The accommodative response to a stationary near target exhibits microfluctuations—small temporal variations in power of up to 0.25 D,48 49 comprising a low frequency component (LFC) of <0.6 Hz and a high frequency component (HFC) of 1.0–2.3 Hz.50 The HFC derives from arterial pulse effects, while the LFC is believed to be important in the maintenance of steady-state accom- modation. Thus, examination of the microfluctuations may give an insight into the accuracy of the negative feedback control system of the accommodative response to any stimuli,51 including digital screens. Iwasaki and Kurimoto52 reported increased microfluctuations after VDT use, but not after paper work. However, their anal- ysis of microfluctuations (from 0 Hz to 1.5 Hz) did not permit differentiation between the LFC and HFC. Gray et al51 explored microfluctuations in five asymptomatic young adults performing a 20 min task with five different displays, including hard copy, cathode ray tube and LCD. Overall, no change in the LFC or HFC was observed as the task progressed, and no difference between display types was reported. One subject did display a significant increase in LFC power at the conclusion of tasks, particu- larly for hard copy and electroluminescent panel display. Analysis of microfluctuations could prove more valu- able in symptomatic individuals, providing information on subtle changes in the accommodative response with different display conditions, although this parameter has been studied relatively little in relation to DES, possibly due to the highly specialised laboratory requirements.

Accommodative facility, the ability to make rapid changes in accommodation response, may be pertinent to computer use, as switching fixation from the screen to other material or into the distance occurs frequently. Among 153 symptomatic computer users examined at a specialist clinic, poor accommodative facility was the most common diagnosis, detected in 31 (20.3 %) patients.53 Rosenfield et al54 examined accommodative facility in 22 young, visually normal subjects, before and after a 25 min desktop computer task. No significant change in monoc- ular facility was observed, while binocular values improved somewhat post-task. Furthermore, as no relationship was established between symptoms and accommodative facility, the conclusion that poor accommodative facility was not linked to ocular fatigue was made. Whether these results are broadly applicable to sufferers of DES is ques- tionable as these young, visually normal subjects reported relatively low symptom scores, and the task duration may not have been sufficient to result in significant changes in accommodative parameters. Chi and Lin26 highlighted improved sensitivity of several parameters linked to VF, including accommodation power and visual acuity, when task duration was extended from 20 min to 60 min.

Pupillary light reflex and size:

Along with accommodation and convergence, the pupil response is the third component of the near triad. Changes in pupillary characteristics and response have been explored as potential indicators of VF. Monitoring pupil diameter within-task has led to the hypothesis that an increase in pupil size indicates VF, due to detri- mental effects on depth of focus.26 Task type has been shown to influence changes in pupil diameter, with more demanding tasks, such as faster on-screen presen- tation of figures55 and tracking (rather than reading or monitoring), causing greater increases in pupil diam- eter, although only a weak correlation with subjective complaints has been established.26Gray et al51 reported a significant overall increase in pupil size during 20 min tasks on various displays, with the effect observed in 3 of 5 visually normal subjects.

After effects have been reported in up to 33% of individuals following intense near work,56 where the pupil may retain a somewhat constricted state after task completion. Saito et al57 noted reduced pupil diameter and increased amplitude of pupillary reflexes following a prolonged VDT task, postulating that spasms of the sphincter pupillae and ciliary muscle may be responsible. Dynamic recording of pupil size and refractive error using an open-view autorefractor as described by Gray et al51 could facilitate analysis of post-task pupil recovery when after effects are present while also enabling study of within task accommodative response (accuracy) and pupil size.

Aggravating factors and management of DES:

Numerous factors are believed to contribute to DES, and it has been asserted that a combination of symp- tom-inducing factors may increase the magnitude of symptoms.58 Therapeutic interventions may be broadly separated into treatment of dry eye, correction of refrac- tive error and management of accommodation and vergence anomalies. The use of commercially available blue-blocking spectacle lenses as a possible treatment for DES has also attracted some interest recently.

Management of dry eye:

Dry eye is considered a significant aetiology of DES, with factors such as altered blinking characteristics, environ- mental influences and gaze angle considered relevant  to dryness with digital device use. Office environments commonly feature low humidity, ventilation fans, air conditioning and airborne dust/toner particles, which may promote corneal drying.59 Desktop computer screens are frequently viewed in horizontal gaze, thus the palpe- bral aperture is wider than for conventional reading tasks (or laptop/tablet use), which are usually performed in downgaze. Consequently, a larger ocular surface area is exposed to the effects of tear film evaporation.58 59

Use of lubricating eye drops has been shown to reduce symptoms such as tiredness, dryness and difficulty focusing during sustained computer use,60 although complete resolution of symptoms may not occur.61 A randomised controlled study of 478 symptomatic computer users (>3 hours per day) demonstrated a beneficial effect of dietary supplementation with omega-3 fatty acids on dry eye signs and symptoms, with 70% in the treatment group being symptom free after 3 months.62

Given the impact of digital device usage on blinking characteristics, blink training may be helpful in the management of DES symptoms linked to dry eye. Increasing blink rate through use of an audible prompt signal every 4 s during a computer task was not found to alter symptom scores,63 although blink efficiency exer- cises to reduce the number of incomplete blinks may be more appropriate given the link between screen use and incomplete blinking.

Refractive error and presbyopia:

Correction of refractive error (notably astigmatism) and presbyopia is accepted as an important intervention in DES sufferers. Double-masked, randomised studies have established that even 0.50–1.00 D of uncorrected simu- lated astigmatism impacts negatively on subjective visual comfort,64 65while 1.00–2.00 D of induced or natural astigmatic error may increase task errors by up to 370% and reduce productivity of computer workers substan- tially.4 Uncorrected astigmatism may be a particular issue among presbyopic patients using off-the-shelf reading spectacles and contact lens wearers with undercorrected or uncorrected cylindrical errors.

The variety of working distances involved in using different digital devices can prove problematic for indi- viduals requiring a near vision add. Small fonts are common on smartphones due to reduced screen size, and a mean working distance of 32.2 cm was established in adults undertaking a web-based smartphone task,66 which may reduce during prolonged viewing.67 Minimum viewing distances of 500–635 mm68 69 have been recom- mended for computer monitors, while working distances of around 500 mm,70 or slightly less with increased age,71 are typical for e-readers. Consequently, a single near add may not provide adequate vision across the range of demand levels, meaning that multiple prescriptions or an occupational correction (eg, combining intermediate and near prescriptions) are required. Computer glasses, with progressive lenses designed to optimise vision in the intermediate and near regions, may reduce symptoms in presbyopic computer users to a greater extent than ergonomic intervention,72while a 2004 study indicated that over a 12-month period, some designs of computer lenses provided greater overall satisfaction and improved subjective evaluation of area of clear vision than single vision spectacles.73

UK employees using display screen equipment  (DSE)

habitually as a significant part of their work are enti- tled to a sight test funded by their employer, along with spectacles specifically for screen use.74 According to College of Optometrists guidance on examining DSE/ computer users,75 practitioners should carry out a full eye examination to determine the cause of any visual problems associated with screen use, ask the patient to describe their workstation and environment and provide appropriate advice including ergonomic information. Despite near-universal use of digital devices, little is known regarding the interpretation of  this  guidance  or how UK optometrists examine and advise patients regarding digital device usage, whether for professional or social purposes. To optimise patient care, increased education of optometrists and opticians regarding DES could be advantageous, given the high prevalence of the condition and continuing research developments in this active field, which may not be covered in detail in under- graduate training programmes.

Accommodation and vergence anomalies:

high lag may reduce visual comfort during nearwork, including computer use. Clinically, accommodative facility may be assessed with plus and minus sphere flipper lenses while the patient fixates a near target, counting the number of cycles ‘cleared’ in 1 min (cpm).76 With the conventional ±2.00 D flippers at 40 cm, 11 cpm has been described as the cut-off between symptomatic and asymp- tomatic adults,76 although more recent research suggests that facility testing should take into account the amplitude of accommodation of individual patients and be scaled accordingly.77 Lag of accommodation is usually assessed by dynamic retinoscopy, with the distance-corrected patient fixating a near target.78 Ophthalmic practitioners should examine visual function at the distances at which screens are used by individual patients58 to ensure clear vision at appropriate task distances. The American Opto- metric Association promotes the 20-20-20 rule (a 20 s break every 20 min to view a distant object at 20 feet) to alleviate DES.10 Frequent short breaks can relax accom- modative and vergence responses, attenuating asthenopic symptoms without impairing productivity.79 80

Vergence dysfunctions include various motor disorders,for example, convergence insufficiency, decompensated heterophoria and poor vergence facility. Individuals with binocular vision problems experience greater visual symptoms with prolonged use of the eyes.81 82 Vergence characteristics have been studied with respect to computer operation, producing mixed results. Watten and colleagues reported significant reductions in vergence ranges (assessed by increasing base in and base out prism power, until blur experienced) at the end of the working day,83 although other authors have shown no differences in vergence functions between individuals involved in computer work and those not using a computer.84–86 Rosenfield et al54 reported no change in vergence facility (ability to make rapid changes in vergence response, using alternate presentation of base out and base in prism) following a 25 min computer task. Later work indi- cated no variation in associated phoria during computer work, although notably, the least symptomatic individuals had a mean associated phoria of 1.55Δ base in, that is,   a slightly reduced vergence response.47 Around 20% of individuals were found to prefer an induced small exo-as- sociated  phoria  compared  with  an  ortho  condition suggesting that CVS may be ameliorated by stimulating an exo-associated phoria in some individuals.58

Blue light:

Exposure to blue light (400–500 nm) can be harmful  to the retina, particularly  suprathreshold,  acute doses,87 88 with peak light damage occurring around 440 nm.89 Longer duration, less intense light exposure can also induce photochemical damage.90While some concern has been expressed regarding blue light emitted from digital screens, recent research indicated that the low levels of blue light from such devices do not repre- sent a biohazard, even for long-term viewing.91 Newer forms of low energy lighting, including LEDs, emit less infrared radiation than their incandescent predecessors, but significantly more blue light leading to the sugges- tion that harmful cumulative exposures could occur.89 92 Theoretically, commercially available blue light-filtering spectacle lenses reduce phototoxicity by 10.6%–23.6%, without degrading visual performance, and have thus been suggested as a supplementary aid for protecting the eyes against the blue light hazard.93

Light exposure is also the main factor involved in setting circadian rhythms. Melatonin hormone is released in dim light conditions and is involved in the physiological control of sleep. Its release from the pineal gland is controlled by a pathway originating from the intrinsically photosensitive retinal ganglion cells containing melanopsin, which has a  peak  sensitivity  of approximately 482 nm,94 that is, longer wavelength blue-turquoise light. Exposure to short wavelength light (including digital devices) before bedtime can disrupt sleep patterns,95 96while use of short wavelength blocking spectacles in the evening can improve sleep duration and quality97 98 and reduce subjective alertness.99

Blue light emitted by digital devices has also been impli- cated as a cause of DES. Isono and colleagues100 reported reduced subjective complaints and smaller reductions in CFF in young adults when reading from a sepia back- ground (reduced blue light contribution) compared with the conventional white background of a modern tablet device. Although cited by Lin et al29 in their rationale for exploring the impact of blue-blocking spectacles on eye fatigue, the small sample size means that the results must be interpreted with caution.

Given both  the  putative  link  between  the  blue  light emitted from modern digital devices and ocular complaints and the commercial availability of blue-fil- tering lenses for treatment of DES, several authors have explored the impact of blue light-reducing spectacles  on symptoms and objective measures of VF29 31 101 (see table 3). There is a lack of consensus in the findings of these studies, and a recent systematic review of the liter- ature called for high-quality research, ideally in the form of randomised control trials, to address the health effects of blue blocking spectacle lenses.102

Cheng et al101 showed no improvement in Schirmer test results when dry eye and non-dry eye participants used low-blocking, medium-blocking and high-blocking wraparound goggles but did report reduced symptoms with all levels of filter in patients with dry eye. Of note  is the lack of a control lens in the study and potential placebo effect, while the wraparound style of goggles means that reduced tear film evaporation in addition   to blue-light reduction may have impacted the results. Following a 2-hour computer task, Ide et al31 reported   a significantly greater reduction in CFF in participants wearing control lenses, compared with those with high or low blue-blocking properties, although no differences in subjective questionnaires were observed between groups. More recently, Lin et al29 measured improved  post-  task CFF in subjects wearing high-blocking spectacles compared with low-block or no block lenses and reported that 3 of 15 symptoms (pain in/around the eyes, eyes feeling heavy and eyes feeling itchy) were lower in the high-blocking group, indicating that short-wavelength filtering spectacles may attenuate both some symptoms of DES and clinical CFF measurement. Notably, the high-blocking spectacles used had an obvious yellow colouration with the transmission spectrum indicating some filtering effect across a range visible wavelengths. Recent research in an animal model has demonstrated that exposure to violet visible light may suppress myopia progression103; if this finding translates to human eyes, there would be implications for use of short-wavelength blocking lenses in young people at risk of myopigenesis or progression.

Author and yearParticipants and methodsKey findings
Cheng et al, 2014101n=20 ‘dry eye’ participants with reduced Schirmer test values.
n=20 with normal Schirmer values.
Wraparound goggles with low-blocking, medium- blocking and high-blocking properties worn for computer work for 1 week each. Schirmer test and subjective questionnaire completed after each week
No significant change in Schirmer test values for any group or filter.
Dry eye participants showed a reduction in ocular complaint scores with all filter levels.
Ide et al, 201531n=33 participants in three groups of 11. Each group wore either high-blocking, low- blocking or control lenses.
Intensive 2-hour computer task completed, with CFF and subjective complaints measured pretask and post-task.
Control group showed significant post-task worsening of CFF compared with high-blocking and low-blocking groups.
No difference in subjective complaints between the three groups
Lin et al, 201729n=36 participants in three groups of 12. Each group wore no blocking, low-blocking or high-blocking spectacles for 2-hour computer task.
CFF and questionnaire completed pretask and post- task.
Post-task reduction in CFF significantly less in high block group. No difference in CFF change between low-block and no block groups.
High-block group reported less pain around/ inside the eyes and less feelings of itchy eyes post-task compared with other groups.

Further to improving subjective comfort, management of DES among computer workers may confer significant economic advantages. The experience of symptoms can reduce work accuracy,104 105 extend the time required to complete tasks4 and necessitate more frequent breaks.12 Following a double-blind study, it was estimated that provision of spectacles to correct small refractive errors in pre-presbyopic employees would increase productivity by at least 2.5%,4 indicating a favourable cost-to-benefit ratio of this intervention. Furthermore, the implemen- tation of short, frequent breaks can enhance working efficiency, adequately compensating for time spent away from the screen.79 106

Conclusions:

Usage of digital devices for work and social purposes, often for many hours each day, is now normal among individuals of all ages. While there are challenges in determining the prevalence of DES, levels of 50% or more have been reported in numerous published studies, indi- cating that a large proportion of the population are at risk, and may seek advice and/or treatment linked to the condition. Eye care professionals are well placed to advise on DES, with professional bodies such as the College of Optometrists (UK) and the American Optometric Asso- ciation providing some guidance for practitioners. To provide optimum patient care related to the condition, it is essential that eye care practitioners are well informed regarding DES and the growing evidence base in this field.

DES symptoms may be split into those linked to dry eye (external symptoms), and internal symptoms related to ametropia, accommodation or vergence problems. Accommodative and/or vergence issues with computer use seem to be a consequence of demanding near work, rather than screen use per se. Nevertheless, such symptoms still require management to promote comfortable viewing. Treatment of dry eye, even mild cases, may have a substantial influence on comfort with screen use.

Questionnaires are of value in evaluating DES as they are simple to implement and capture patient experiences, although validated instruments are rare. In evaluating putative DES treatments, questionnaires have frequently been used alongside objective measures linked to VF, although correlation between objective and subjective assessments has not always been apparent. Regardless of the type of intervention proposed (eg, management of dry eye, correction of refractive error, use of computer spectacles or blue-blocking lenses), persistent effects of treatment should be explored to indicate the true value of DES management options. With the high prevalence of DES and near-universal use of digital devices, it is paramount that the condition is considered by eye care practitioners, and treatment options are supported by available research evidence.

 

Contributors ALS was involved in planning and drafting the manuscript. JSW reviewed and revised the draft. Both authors read and approved the final manuscript.

Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

Competing interests None declared.

patient consent Not required.

provenance and peer review Not commissioned; externally peer reviewed.

open Access This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

 

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